Dr. Benjamin Bikman – ‘Insulin vs. Ketones – The Battle for Brown Fat’

Dr. Benjamin Bikman – ‘Insulin vs. Ketones – The Battle for Brown Fat’


100 Replies to “Dr. Benjamin Bikman – ‘Insulin vs. Ketones – The Battle for Brown Fat’”

  1. Thanks for putting this up. You've provided some of the best information I've found on how insulin comes into play. I now no longer need my Metformin from maintaining a strict Ketogenic lifestyle, but now I understand more about why that is.

  2. but it doesn't make sense, high carb athlete performs much better than high fat low carb diet, just look at Olympic athletes, none of them follows a ketogenic diet. Their performance goes down drastically if they don't eat glucose

  3. An interesting thing that crossed my mind while watching is that when we are getting fat in nature is when we hunt, and to hunt we need to run a lot, and to run a lot we cannot be heavy.

  4. Very cool presentation, I want all my fat to be BAT! haha – but in seriousness, it is very interesting to see the connection between fat tissue with insulin & Ketones.

  5. WoW! Love this talk. My son did the "keto" diet about a year ago and turned me on to watching Dr Berg keto talks on YouTube. I started my keto journey on Dec. 8th, at 477 lbs. As of Feb. 27th (2.5 months), I'm down 50# (427) and couldn't be more ecstatic. My cravings for food are minimal and mostly psychological at this point. I've reduced intake to about 2 meals a day with little interest for more. I do one meal a day "OMAD" at least once a week. I came off my insulin (was taking U-500) within days and am now starting to wean off my blood pressure meds. I really appreciate this deeper dive you've done into the science and that you're making it public. I hope you'll be able to do a collaborative video with Dr Berg soon because I think more people would appreciate the additional evidence. This is life changing affects the person doing it and all around them. Best of luck to you as you continue your work and thank you!

  6. I am wondering if nature is really so stupid and made the carb preferable food for our brains? And now, we the "smart" people will fix this mistake of nature? Ha ha ha… And guys, when you talk about carbs… please talk about natural carbs, ( whole nature food), not a "smart" man-made carbs. And yes, insulin is a poison, therefore we should get rid of it :)))

  7. This sounds wonderful but how can we be sure we’re not trading type 2 diabetes and obesity for heart disease?

  8. What people are completely unaware of, (and in my opinion the scientists don't emphasize this enough), is that metabolic rate varies depending on what you eat and how often you eat.

    It doesn't vary a little bit, but enormous. Metabolic rate between 2 people with equal health, same weight and bodyfat percentage, on different diets of the same amount of calories, can be different as much as 50%. Fifty percent!!!!!

    Reducing calories just drops your metabolic rate by about the same amount of calories. Nobody seems to be aware of this.

    The problem is that this effect is somewhat hidden because it's not instant. At first you burn through glycogen. Glycogen stores are about 2 to 3 kg of glucose and water and they are in the muscle and liver. That's the first week of dieting. After that first week, the metabolic rate starts to drop to match the caloric intake. And it's when the real suffering starts: Feeling cold, constantly thinking about eating, living from meal to meal, grumpiness, etc.

    If people could only really understand these shifts in metabolic rates, they wouldn't even try to just simply cut calories.

    It is weird as hell. I've explained this to people and even if they say they understand, the only possible effect is that they start a low calory diet because they became aware (again) they need to lose some weight. It's like trying to convince mormons that god doesn't exist. A total waste of time.

  9. Interesting video and theory. But there is one thing I'm not sure about: why would wasting more energy be a good thing? I understand the concept of burning it, but wasting more energy (than usual) would surely be counterproductive especially when food supply is scarce.

  10. For the record babies don’t shiver because they have brown fat. They have brown fat because they don’t have muscle which is required to shiver. In other words he has it the wrong way around. Babies lose their fat as they develop muscle.

  11. I love this mans brain! My favourite fat is scrapped off my fatty roasts!yummy:)Brilliant lecture Proffesor,now go teach our M.Ds some real science( please).

  12. Perhaps my access body fat I'm still hanging on to isn't as unhealthy as I thought. Maybe my body doesn't want to "waste energy" so it hangs onto it and stores it quite easily. 🤔

    It kinda makes sense now why people say "just stick with it" and six months later they suddenly begin to see results of more muscle tone happening.

  13. Interesting how the endocrine theory engulfs the caloric theory – you explained this really well! I also never realized that that there are two different kinds of fat tissue: white and brown…fascinating!

  14. there really are no real scientific difference in the 2 theories – it's just that the energy out has more channels than the caloric theory accounts for, that's all..

  15. I am thankful that you have given us the science behind the keto diet.
    Im finally losing the fats.
    I didnt count calories, however, now I do because eating proteins and maybe a little to much fat (which was measured in tablespoons) causes me to retain fat. I can only assume im extremely insulin resistant.

    So very thankful for this research!

  16. Hello doctor!just recently I read somewhere that low carb diet can potentially increase insulin resistance in long term & also increase risks of heart disease,etc..can u pls comment on long term risks of Keto/low carb?

  17. So at 28:55, I conclude that when a body becomes type2 diabetic, its actually the bodies way of regulating body fat. Is that correct? It stops creating insulin in order to force itself to run on keytones and strip away bodyfat. And medical intervention only ends up interrupting that process which proves only to exacerbate into a illness.

    Please confirm my understanding that type2 is a corrective action brought on by the body.

  18. 25:12 I once did some calculations based on the mmols on a ketostix for piddling on and worked out that not many ketones in absolute terms ended up in my urine. Was I wrong? how many Kcals actually end up in your urine? Ok Here are the calculations 3 mmol/L = 17.5mg/dL = 175 mg/L = 1gram per 5.7 litres of Urine. 1 gram Ketones = 9 Kcal I guess, so nearly 6 litres of urine (over 1.5 gals) = 9 Kcal Are these calculations right or wrong?

  19. So has a diabetic type 2 I should avoid taking metformin or insulin and just stick to a low carb diet/keto??

  20. DR. Bickman mentions pairing up with a bariatric clinic to test the patients – has that testing/study/ findings been published yet?

  21. – 3 Reasons Why Bulletproof Coffee is a Bad Idea and the dangers of long term on a ketogenic diet .
    Humans did NOT evolve eating (or drinking) such massive amounts of saturated fat.
    There are plenty of nutrients that are healthy when consumed in reasonable amounts, but when people start megadosing them it can cause serious problems.

    One example is fructose… it's "good" when found in nutritious, fibrous whole fruit, but a disaster when consumed in massive amounts from refined sugars (6, 7).

    Another example is linoleic acid (the main Omega-6 fat)… it's healthy when found in whole, nutritious nuts, but a disaster when consumed in massive amounts from veggie oils (8, 9, 10).

    It is entirely possible that saturated fat is the same. Healthy in reasonable amounts, but harmful when we start eating massive, unnaturally large doses that are way outside of evolutionary norms.There are plenty of nutrients that are healthy when consumed in reasonable amounts, but when people start "megadosing" them it can cause serious problems.

    One example is fructose… it's "good" when found in nutritious, fibrous whole fruit, but a disaster when consumed in massive amounts from refined sugars (.

    Another example is linoleic acid (the main Omega-6 fat)… it's healthy when found in whole, nutritious nuts, but a disaster when consumed in massive amounts from veggie oils (8, 9, 10).

    It is entirely possible that saturated fat is the same. Healthy in reasonable amounts, but harmful when we start eating massive, unnaturally large doses that are way outside of evolutionary norms.

    ——BOTTOM LINE:
    There have been numerous reports of people having massive increases in cholesterol levels when drinking bulletproof coffee. This includes advanced risk factors like ApoB and LDL particle number.

    I personally think it is best to proceed with caution when adopting a drastic dietary change that has never been tested and is way outside of evolutionary norms. It is better to be safe than sorry.

    —Another trend a slow unhealthy liver cannot metabolize and process eating so much fat 7 days a week .
    ..sooner or later your liver it clogs up .

    " ketogenic diet " –In the study, the researchers fed mice a ketogenic diet for several days and expected to find a favorable outcome — perhaps weight loss or another indication of improved health. Instead, they found that the "liver began resisting" insulin" almost immediately and the mice were unable to regulate their blood sugar levels after only "three days" on the diet. (Insulin resistance, meaning that cells in the body don't respond to insulin, is a key characteristic of type 2 diabetes.)😮 Go to this website to read Article on keto diet .

    https://www.livescience.com/63306-ketogenic-diet-diabetes-risk.html?utm_content=buffer128c4&utm_medium=social&utm_source=facebook

    —Many people follow ketogenic diets for weight loss and other health benefits. A ketogenic diet can be an effective means to lose weight, reverse type 2 diabetes, fatty liver, and other health conditions.

    The problems come, however, when you follow a ketogenic diet for an "extended period" . We already know from the many children who have followed a ketogenic diet to suppress seizures that they are at least 10-fold greater risk for kidney stones, impaired growth, dysbiosis, and metabolic distortions.

    If you follow a ketogenic diet, you MUST address bowel flora, especially with prebiotic fibers. And you would be well advised to not remain ketotic for extended periods else you are at substantial risk for dysbiosis, constipation, diverticular disease, and "colorectal cancer" .

    Great video to watch if you're on a ketogenic diet ;

    https://www.youtube.com/watch?v=O9R-HttnhyM

  22. We've been living off carbs for so long that we think of the emergency energy source (glucose) is the normal source and the normal sources (fat and protein) are the backups.
    Glucose is a quick and dirty way to supply energy and to store up fat in times that fat and protein are scarce

  23. Such a dangerous message. Please study the work of Esselstyn, McDougall, Campbell, Popper, Fuhrman, Goldhamer and other Plant Based doctors. Most of all STUDY THE WORD OF WISDOM! Part of your faith! Wheat is for man, fruit is for man, and he even tells us “It pleases me if you only eat meat in time of famine cold and winter.” Insulin sensitivity can return when you eliminate fat from your diet. The cells that are full of fat release the fat and can now accept glucose. Your message is encouraging and adding to insulin resistance. There is so much more to this than not using your insulin. Are you teaching this to your students at BYU? Dangerous.

  24. I was wondering if on the flip side of this, can this endocrine theory account for why so many people say they feel cold when their insulin is high as a result of a high sugar diet?

  25. DR Bikman is an amazing presenter, objective, articulate. Not the least bit offensive or obnoxious like some. It is a pleasure to watch and listen.

  26. Its kinda of like a catalytic converter in a car's exhaust burning off unused energy on exit of the system. It creates heat and blows it out with no gain to the system in mpg or future energy needs in the system. Except the car can't decide to store it when exhaust system is malfunctioning.

  27. Another question for anyone who knows their stuff:
    What is the adaptive theory for us "wasting" energy by urinating out "parts of fat", ie ketones?
    It seems to me that would be highly selected against from an evolutionary/adaptive point of view.
    Is it just a biochemical necessity to get at the fat energy?

  28. Just wondering: Energi waste of ketones in the breath and in the urin is OK. But what about the enrgi lost to heat? There are no substances in heat? E=mc2. Isnt heat just radiation? You cant loose weight just by heat? Is it that the "exhaust" from the heat-produced is CO2 from the cell and we breath that out as well?

  29. Get people on a keto diet and put them in a cold pool for 30 minutes a day. Do the same with people on a regular diet. Do that for a month and see if anything interesting falls out.

  30. Brilliant talk, chock full of scientific information which will take many views by this totally biomedical- ignorant person to understand and absorb.

  31. Thank you for yet another clear and informative presentation.
    One question that remains is to understand to what point ketones themselves have an effect on the metabolic pathways and cellular inflammation and to what extent they are merely an index of the glucose shortage and the opening of the decarboxylation pathway.

    Do ketones have an anti-inflammatory effect or does the glucose shortage starve intracellular germs and viruses that produce inflammation?

    In so many ways, the valiant band of metabolic explorers you represent remind me of the feats of Livingston and Stanley discovering Africa.

  32. Cool. Like your car, fuel is stored, used for powering the wheels, used to heat the cabin, or dumped to the air via the radiator.

  33. I have been cutting out the carbs to lower my A1C blood sugar level ( up to 5.7 ) …..problem is I don't want to lose anymore weight, as I am 5' 11" and 155 lbs ( I was 165 lbs 2 weeks ago ) ……what exactly should I be eating to maintain weight and still cut out the carbs …..thanks

  34. IMPORTANT QUESTION: The first study when they created hyperinsulenimia in the mouse, how was this accomplished? It showed a picture of a syringe. If this was not done through high glycemic food and rather through injection, then this study and this conclusion, is completely false and misleading. Please provide the link to the study, and explain how hyperinsulinemia was achieved. Scientists like to find data that suits their agenda. I hope that this is not the case in this video.

  35. Thank you.
    Once the weight loss settles …
    I'd like to know how we as individuals can identify when and if we are converting our white fat to brown fat and what are the visual indicators that prove we are doing this (apart from weight loss) – especially once our weight loss subsides. Is it then the addition of exercise is required ??? that will be the trigger for that exchange?

  36. Thank you, Professor Bikman! You have explained the complex metabolic reaction of our bodies to carbohydrates, protein, and fat so clearly that I think even a fairly uninformed person can understand the role of carbohydrates and insulin in fat deposition. I am going to point out your presentation to several type 2 diabetics who think I’m nuts for controlling my type 2 Diabetes strictly through diet—a diet greatly made up of—OH HORRORS—FAT!

  37. Since I am always cold, I wish he explained how we could make more brown fat cells or make those bitches work freaking harder! Why the hell am I always cold?!

  38. I have a question, in ketosis we take most of the energy from the fat and insulin is low to start ketosis…fruits neither spike insulin and most of them ie 80% of fructose get stored in the liver and only 20% goes to muscle in the form of glucose …
    so actually both the criteria of ketosis is matched ..so why cant we take fruits in ketosis please enlighten me

  39. What an amazing presentation. For me, as a non-academic (certainly non-scientific or medical), this made complete sense and was easy to understand – the use of the slides to support / explain the findings was great (ok – I DID have to pause a few of the slides to make sure I understood the graphical correlations).

    I hear some recent concerns about keto diet effects on the kidneys for diabetics. I'm Type 2 – although moderating my diet so comfortably at pre-diabetic levels. Would be keen to hear if there has there been any new information since this presentation that might be relevant to diabetics.

  40. This was a great presentation, thanks for the upload I will watch it over again.

    Why can't I comment on Individual comments?
    I think YouTube is blocking me.

    Maybe I've said something wrong.

  41. Dr Bikman, You said we need insulin to make a fat cell from stem… can we kill (apoptosis) fat cells from staying in ketosis for prolonged periods? in essence starving them of their motivator? Thanks, Mike

  42. good stuff. makes sense. working for me. eat till you are full. low carb. good fat. good, modest protein….easy as pie.

  43. so why does the body spend valuable energy to convert fat ad protein into glucose, if glucose is not important?

  44. very well done Doc Bikman & thank you for talking about function, just another reason why i did not pass microbiology in juco college (twice) five star *****5*****especially at a time when the Wim Hoff method is being used & in your words may be "remarkably related".

  45. Uses green to colour the brown fat icon – WWWWWWWHHHHHHHHHHHYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY????????????????

    My goals for 2019:
    IF + KETO + Meditation + Qigong + Wim Hoff
    75%FATS/20%PROT/5%CARB = LCHF4Life

    We all die – it’s how we choose to live that matters …

    Science helps inform decision making
    Spirituality lifts your potential to its highest blossoming

    Body is flow
    Mind is flux
    Soul is Choice

    Loving, living and learning

    Thank you Doctor Benjamin

  46. Excellent talk…Good for those on Keto and also for those in Intermittent fasting. A must watch for Diabetics to understand more about what's going on in their bodies.

  47. Although not speaking to some very important mechanisms, this was a very informative lecture.

    Having said that, with time restricted feeding, I eat nothing but green, yellow,and starchy vegetables, the occasional fruit, legumes,, select whole intact grains and seeds yet have fasting insulin levels below “normal” 🤔 range. I also WOF (nature’s true keto) for 2 days, 64 hours, as occasional resets .Curious.

    mTOR, IGF-1, telomeres all good

  48. A very informative talk! However, as a next step would be interesting to understand wider physiological effects of the ketogenetic diet, I.e. cardiovascular health, dementia and cancer. As well, if this type of diet can be used during the whole human life span or only at certain pre-diabetic states. Again, well done!

  49. I was just looking for this. I am very satisfied with this presentation. Thanks for this great informative video.

  50. Ketogenic wasting probably includes perspiration as well as the other two means because my body odor changes during ketosis indicating that sweat may be another way to waste.

  51. So, where does Ketoacidosis come into this, or, by 'high' ketones, do you mean still below this level? Because this sounds dangerously close to the abuse a Type 1 diabetic can wreak on themselves in order to lose weight.

  52. Not sure, I may have already posted. But this KWOE has changed my life. Today, I am down a whopping -99 lbs. BP 118/68. Fasting morning BS 94. This thumbnail was me at 305lbs. Today 206…still a way to go, but I'm so grateful for the truthful science Dr. Bikmen shares with us. LCHF is practically effortless in month #10. My body prefers fat for fuel. Thank you, Thank you, Thank you!!!

  53. I'm confused. Many of us have been told by doctors, hospitals & even the internet, that brown fat is dangerous. R U saying that it's actually beneficial to adults?

  54. Any help would be appreciated, it seems impossible to eat over 1200 calories, I don't mind eating some fat (Bacon, porkroll, scrapple, etc), but other than that, living on meat, sardines, eggs, cream, butter, etc is resulting in reduced caloric intake, my concern is about metabolic rate reduction due to reduced caloric intake.

  55. I'm about 2 weeks into keto diet and I was thinking about the wasting part of the ketone diet as well. Have someone don the math on how many calories one would waste just by pissing and breathing out ketones?

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