Stem Cell Muscle Treatment

Stem Cell Muscle Treatment

Hi, this is Dr. Centeno. And today, I’d like to talk
about how stem cells are involved with muscle atrophy. Most patients don’t
understand that if you’re having a hard time recovering
from an orthopedic injury, it could be because
of muscle atrophy. In the shoulder, for
instance, if you’ve got muscle atrophy on
MRI or fatty infiltration of the muscle, you’re much less
likely to recover from surgery for a rotator cuff tear. And in the low back,
they don’t realize that if you’ve got
chronic back pain, there’s a very
good chance you’ve got severe or significant
muscle atrophy on your MRI of the stabilizing
muscles of the back. So this muscle atrophy
thing is a really big deal. Now there’s some
recent research that can tell us about
how this happens, and in fact, how it happens
at a cellular level involving stem cells. And the article
is quite complex, but I’m going to boil it down
here to just a few minutes. So basically,
within your muscles you have these
fibro-adipogenic progenitors. They’re kind of like mini
stem cells, if you will. And they have a switch on them. And if the switch
is turned one way, those cells become
normal muscle. But if the switch is
turned the other way, those cells can turn
into fat or scar tissue. So interesting that
this tends to mirror what we see in patients
who get muscle atrophy. And the question is, what
causes that switch to flip? So if we look at the
article, the article’s got some very wonderfully drawn
but pretty complex diagrams, so I’m going to boil
all that down for you. So basically, what happens is
that you have these FAP cells and stem cells. And those muscles stem
cells talk back and forth to the FAP cells via IL-6. And IL-4 turns bad macrophages
into good macrophages, and helps the FAP cells
turn into normal muscle. But if you inhibit
IL-4, you end up getting the fatty or scarred
muscle, which is muscle atrophy and not good for recovery. So for all practical
purposes, what happens if your FAP cells
are exposed to steroid shots, for instance, that inhibit
IL-4 or just a patient who has impaired
insulin sensitivity, chronic inflammation
and metabolic syndrome? Then you get fatty
atrophy or scarring atrophy of the muscles. On the other hand, if you’ve got
a patient who has good insulin sensitivity, who exercises and
controls their inflammation, and they express
normal levels of IL-4, you’ll get normal muscle. So the upshot is, as
many other studies show, metabolic syndrome, which
is weight gain, inactivity, high blood pressure, high
triglycerides, and prediabetes wrecks havoc on all of our
cells and dramatically decreases our life span and
our quality of life. But in particular, it
causes these problems and it makes this muscle atrophy
much worse at a cellular level. So what’s interesting
to think about is that since bone marrow
concentrate but not fat stem cells are rich in
hematopoietic stem cells, and these can replace
muscle stem cells based on other research, it’s
not unreasonable to think that perhaps those kinds
of injections in the muscle could help muscle
atrophy in patients without metabolic syndrome. And perhaps that’s why we see
some of the things we see. For instance, some
of the research showing that if you inject bone
marrow concentrate into healing rotator cuff muscles that you
have half the re-tear rate after surgery. Could it be that what
you’re really doing is treating that
muscle atrophy that allows so many patients
to get re-tears, and that allows– and causes
so many patients to be quite miserable for such a long time? Well, that’s it. Thanks for watching. And always happy to take
a very complex issue and try to boil it down
into something simple.

One Reply to “Stem Cell Muscle Treatment”

  1. Dr. Centeno, I've done 2 PRP and lysate inj. with Dr. Bashir, and I'm still experiencing stabilizing muscle atrophy in my cervical spine, my atlas is subluxed, causing facial, neck pain and instability ( turning my head is causing pain and immobility in my upper body and face…..along with high blood pressure at times.) As a mom of 5, and a medical assistant I'm not able to do a lot at this time, and I'm seeking treatment for this injury without surgery. Are there any stem cell studies I can join (not seeking any compensation?) Any help or advice is much appreciated as this condition is progressing and I feel stuck. Thank you for your work and informational advisement, it does give me hope 🙂

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